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METABOLISM

The return of quiescence metabolites

Nature Cell Biology volume 23, pages 303–304 (2021)Cite this article

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The transition of endothelial cells between quiescence and proliferation is essential for regulating the extent of the vasculature that supplies oxygen and nutrients to tissues. A study now shows that the FOXO1 transcription factor regulates endothelial cell proliferation by controlling levels of the metabolite 2-hydroxyglutarate.

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Fig. 1: Schematic of proposed regulatory pathway.

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Acknowledgements

The author would like to acknowledge support from NCI R01 CA221296, R01 AR070245, the Melanoma Research Alliance, the Cancer Research Institute, the Broad Stem Cell Center, and the Jonsson Comprehensive Cancer Center.

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Authors and Affiliations

  1. Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA

    Hilary A. Coller

  2. Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, CA, USA

    Hilary A. Coller

  3. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA

    Hilary A. Coller

  4. Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA

    Hilary A. Coller

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  1. Hilary A. Coller
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Correspondence to Hilary A. Coller.

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Coller, H.A. The return of quiescence metabolites. Nat Cell Biol 23, 303–304 (2021). https://doi.org/10.1038/s41556-021-00640-x

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