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Tumour-regulated anorexia preceding cachexia

Anorexia commonly develops in patients with advanced cancer and is closely associated with cachexia. A new study shows that anorexia emerges earlier than cachexia in both Drosophila and mouse tumour models and that tumour-derived humoral factors induce anorexia by systemically dysregulating neuropeptides in the brain.

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Fig. 1: Schematic illustration depicting the systemic effects of cancer.
Fig. 2: Cancer-induced dysregulation of neuropeptides promotes anorexia, which is initiated prior to and independent of cachexia onset.


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Correspondence to Haiying Zhang or David Lyden.

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Wang, G., Zhang, H. & Lyden, D. Tumour-regulated anorexia preceding cachexia. Nat Cell Biol 23, 111–113 (2021).

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