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CANCER

Tumour-regulated anorexia preceding cachexia

Anorexia commonly develops in patients with advanced cancer and is closely associated with cachexia. A new study shows that anorexia emerges earlier than cachexia in both Drosophila and mouse tumour models and that tumour-derived humoral factors induce anorexia by systemically dysregulating neuropeptides in the brain.

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Fig. 1: Schematic illustration depicting the systemic effects of cancer.
Fig. 2: Cancer-induced dysregulation of neuropeptides promotes anorexia, which is initiated prior to and independent of cachexia onset.

References

  1. 1.

    Schmidt, S. F., Rohm, M., Herzig, S. & Berriel Diaz, M. Trends Cancer 4, 849–860 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Fearon, K. et al. Lancet Oncol. 12, 489–495 (2011).

    Article  Google Scholar 

  3. 3.

    Inui, A. CA Cancer J. Clin. 52, 72–91 (2002).

    Article  Google Scholar 

  4. 4.

    Kwon, Y. et al. Dev. Cell 33, 36–46 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Figueroa-Clarevega, A. & Bilder, D. Dev. Cell 33, 47–55 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Wang, G. et al. Nat. Med. 24, 770–781 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Yeom, E. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-00628-z (2021).

  8. 8.

    Vallejo, D. M., Juarez-Carreño, S., Bolivar, J., Morante, J. & Dominguez, M. Science 350, aac6767 (2015).

    Article  Google Scholar 

  9. 9.

    Schwartz, M. W., Woods, S. C., Porte, D. Jr., Seeley, R. J. & Baskin, D. G. Nature 404, 661–671 (2000).

    CAS  Article  Google Scholar 

  10. 10.

    Zhang, H. et al. Nat. Cell Biol. 20, 332–343 (2018).

    CAS  Article  Google Scholar 

  11. 11.

    Peinado, H. et al. Nat. Med. 18, 883–891 (2012).

    CAS  Article  Google Scholar 

  12. 12.

    Anker, M. S. et al. J. Cachexia Sarcopenia Muscle 10, 22–34 (2019).

    Article  Google Scholar 

  13. 13.

    Ezeoke, C. C. & Morley, J. E. J. Cachexia Sarcopenia Muscle 6, 287–302 (2015).

    Article  Google Scholar 

  14. 14.

    Argilés, J. M., Busquets, S., Stemmler, B. & López-Soriano, F. J. Curr. Opin. Pharmacol. 22, 100–106 (2015).

    Article  Google Scholar 

  15. 15.

    Peinado, H. et al. Nat. Rev. Cancer 17, 302–317 (2017).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Haiying Zhang or David Lyden.

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Wang, G., Zhang, H. & Lyden, D. Tumour-regulated anorexia preceding cachexia. Nat Cell Biol 23, 111–113 (2021). https://doi.org/10.1038/s41556-021-00635-8

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