Shear stress turns on the primary cilium and lipophagy

While the formation and concentration of urine are better understood, how kidney epithelial cells generate the energy to drive these functions has remained unclear. A study now reveals that shear stress originating from urinary flow is sensed by the primary cilia of cortical epithelial cells and stimulates lipolysis and oxidative metabolism.

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Fig. 1: A primary cilium–lipophagy axis supplies energy to kidney epithelial cells.


  1. 1.

    Praetorius, H. A. Am. J. Physiol. Cell Physiol. 308, C198–C208 (2015).

    CAS  Article  Google Scholar 

  2. 2.

    Tang, Z. et al. Nature 502, 254–257 (2013).

    CAS  Article  Google Scholar 

  3. 3.

    Pampliega, O. et al. Nature 502, 194–200 (2013).

    CAS  Article  Google Scholar 

  4. 4.

    Boya, P., Reggiori, F. & Codogno, P. Nat. Cell Biol. 15, 713–720 (2013).

    CAS  Article  Google Scholar 

  5. 5.

    Singh, R. et al. Nature 458, 1131–1135 (2009).

    CAS  Article  Google Scholar 

  6. 6.

    Orhon, I. et al. Nat. Cell Biol. 18, 657–667 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Miceli, C. et al. Nat. Cell Biol. (2020).

  8. 8.

    Settembre, C. et al. Nat. Cell Biol. 15, 647–658 (2013).

    CAS  Article  Google Scholar 

  9. 9.

    Rosenbaum, A. I. et al. Biochim. Biophys. Acta 1791, 1155–1165 (2009).

    CAS  Article  Google Scholar 

  10. 10.

    Zimmermann, R. et al. Science 306, 1383–1386 (2004).

    CAS  Article  Google Scholar 

  11. 11.

    Martinez-Lopez, N. et al. Cell Metab. 23, 113–127 (2016).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Rajat Singh.

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Martinez-Lopez, N., Singh, R. Shear stress turns on the primary cilium and lipophagy. Nat Cell Biol 22, 1029–1030 (2020).

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