While the formation and concentration of urine are better understood, how kidney epithelial cells generate the energy to drive these functions has remained unclear. A study now reveals that shear stress originating from urinary flow is sensed by the primary cilia of cortical epithelial cells and stimulates lipolysis and oxidative metabolism.
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Martinez-Lopez, N., Singh, R. Shear stress turns on the primary cilium and lipophagy. Nat Cell Biol 22, 1029–1030 (2020). https://doi.org/10.1038/s41556-020-0571-3
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DOI: https://doi.org/10.1038/s41556-020-0571-3
