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Igniting the spread of ferroptotic cell death

Ferroptosis is an iron-dependent mode of cell death driven by lipid peroxidation, capable of explosively propagating through a field of cells. Two studies now explore the mechanisms underlying ferroptotic cell death and its spread, as well as its possible in vivo significance, shedding light on some of the burning questions surrounding ferroptosis.

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Fig. 1: Cell–cell propagation of ferroptosis is a distinct step from ferroptotic cell lysis.
Fig. 2: Lipid peroxidation is utilised as a long-range communication system to relay inflammatory signals to recruit leukocytes (green), despite the risk of inducing catastrophic spread of ferroptosis.


  1. 1.

    Galluzzi, L. et al. Cell Death Differ. 25, 486–541 (2018).

    Article  Google Scholar 

  2. 2.

    Green, D.R. Cell Death: Apoptosis and Other Means to an End. 2nd edn. (Cold Spring Harbor Laboratory Press, New York, 2018).

  3. 3.

    Degterev, A. et al. Nat. Chem. Biol. 1, 112–119 (2005).

    CAS  Article  Google Scholar 

  4. 4.

    Medina, C. B. et al. Nature 580, 130–135 (2020).

    CAS  Article  Google Scholar 

  5. 5.

    Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    CAS  Article  Google Scholar 

  6. 6.

    Yang, W. S. et al. Proc. Natl Acad. Sci. USA 113, E4966–E4975 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Linkermann, A. et al. Proc. Natl Acad. Sci. USA 111, 16836–16841 (2014).

    CAS  Article  Google Scholar 

  8. 8.

    Riegman, M. et al. Nat. Cell Biol. (2020).

  9. 9.

    Katikaneni, A. et al. Nat. Cell Biol. (2020).

  10. 10.

    Stockwell, B. R. et al. Cell 171, 273–285 (2017).

    CAS  Article  Google Scholar 

  11. 11.

    Yang, W. S. et al. Cell 156, 317–331 (2014).

    CAS  Article  Google Scholar 

  12. 12.

    Niethammer, P., Grabher, C., Look, A. T. & Mitchison, T. J. Nature 459, 996–999 (2009).

    CAS  Article  Google Scholar 

  13. 13.

    Enyedi, B., Kala, S., Nikolich-Zugich, T. & Niethammer, P. Nat. Cell Biol. 15, 1123–1130 (2013).

    CAS  Article  Google Scholar 

  14. 14.

    Evans, I. R., Rodrigues, F. S., Armitage, E. L. & Wood, W. Curr. Biol. 25, 1606–1612 (2015).

    CAS  Article  Google Scholar 

  15. 15.

    Weavers, H. et al. Curr. Biol. 26, 1975–1989 (2016).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Will Wood.

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Davidson, A.J., Wood, W. Igniting the spread of ferroptotic cell death. Nat Cell Biol 22, 1027–1029 (2020).

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