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IMMUNOLOGY

The hidden side of PD-L1

Nature Cell Biology volume 22, pages 1031–1032 (2020)Cite this article

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PD-L1 has been extensively described as the membrane-bound ligand of PD-1. A recent study discovered a previously unknown role for PD-L1, which is able to bind DNA and thus govern different pathways linked to either evasion of immune surveillance or tumour microenvironment inflammation.

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Fig. 1: De-acetylation-dependent PD-L1 nuclear translocation supports tumour immune evasion.

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Authors and Affiliations

  1. Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland

    Alison Jaccard & Ping-Chih Ho

  2. Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland

    Alison Jaccard & Ping-Chih Ho

Authors
  1. Alison Jaccard
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  2. Ping-Chih Ho
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Correspondence to Alison Jaccard or Ping-Chih Ho.

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The authors declare no competing interests.

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Jaccard, A., Ho, PC. The hidden side of PD-L1. Nat Cell Biol 22, 1031–1032 (2020). https://doi.org/10.1038/s41556-020-0568-y

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