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The hidden side of PD-L1

PD-L1 has been extensively described as the membrane-bound ligand of PD-1. A recent study discovered a previously unknown role for PD-L1, which is able to bind DNA and thus govern different pathways linked to either evasion of immune surveillance or tumour microenvironment inflammation.

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Fig. 1: De-acetylation-dependent PD-L1 nuclear translocation supports tumour immune evasion.


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Correspondence to Alison Jaccard or Ping-Chih Ho.

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Jaccard, A., Ho, PC. The hidden side of PD-L1. Nat Cell Biol 22, 1031–1032 (2020).

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