STEM CELLS

A transitional stem cell state in the lung

Studies of stem cell behaviour during regeneration have largely focused on understanding how cells make the choice between self-renewal and differentiation. It remains unclear whether cells undergo smooth transitions during differentiation or pause at selective intermediate states. Three studies now explore this question in lung regeneration.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Response of the lung alveolar epithelial cells to injury.

References

  1. 1.

    Zepp, J. A. & Morrisey, E. E. Nat. Rev. Mol. Cell Biol. 20, 551–566 (2019).

    CAS  Article  Google Scholar 

  2. 2.

    Kathiriya, J. J., Brumwell, A. N., Jackson, J. R., Tang, X. & Chapman, H. A. Cell Stem Cell 26, 346–358.e4 (2020).

    CAS  Article  Google Scholar 

  3. 3.

    Rock, J. R. et al. Proc. Natl Acad. Sci. USA 108, E1475–E1483 (2011).

    CAS  Article  Google Scholar 

  4. 4.

    Barkauskas, C. E. et al. J. Clin. Invest. 123, 3025–3036 (2013).

    CAS  Article  Google Scholar 

  5. 5.

    Frank, D. B. et al. Cell Rep. 17, 2312–2325 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Nabhan, A. N., Brownfield, D. G., Harbury, P. B., Krasnow, M. A. & Desai, T. J. Science 359, 1118–1123 (2018).

    CAS  Article  Google Scholar 

  7. 7.

    Zacharias, W. J. et al. Nature 555, 251–255 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    LaCanna, R. et al. J. Clin. Invest. 129, 2107–2122 (2019).

    Article  Google Scholar 

  9. 9.

    Finn, J. et al. Cell Rep. 26, 2942–2954.e5 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Dorry, S. J., Ansbro, B. O., Ornitz, D. M., Mutlu, G. M. & Guzy, R. D. Am. J. Respir. Cell Mol. Biol. 62, 608–621 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Yuan, T. et al. Stem Cell Rep. 12, 1041–1055 (2019).

    CAS  Article  Google Scholar 

  12. 12.

    Zepp, J. A. et al. Cell 170, 1134–1148.e10 (2017).

    CAS  Article  Google Scholar 

  13. 13.

    Lee, J. H. et al. Cell 170, 1149–1163.e12 (2017).

    CAS  Article  Google Scholar 

  14. 14.

    Kobayashi, Y. et al. Nat. Cell. Biol. https://doi.org/10.1038/s41556-020-0542-8 (2020).

  15. 15.

    Strunz, M. et al. Nat. Commun. https://doi.org/10.1038/s41467-020-17358-3 (2020).

  16. 16.

    Choi, J. et al. Cell Stem Cell https://doi.org/10.1016/j.stem.2020.06.020 (2020).

  17. 17.

    Wu, H. et al. Cell 180, 107–121.e17 (2020).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Xin Sun.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Verheyden, J.M., Sun, X. A transitional stem cell state in the lung. Nat Cell Biol 22, 1025–1026 (2020). https://doi.org/10.1038/s41556-020-0561-5

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing