Studies of stem cell behaviour during regeneration have largely focused on understanding how cells make the choice between self-renewal and differentiation. It remains unclear whether cells undergo smooth transitions during differentiation or pause at selective intermediate states. Three studies now explore this question in lung regeneration.
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Verheyden, J.M., Sun, X. A transitional stem cell state in the lung. Nat Cell Biol 22, 1025–1026 (2020). https://doi.org/10.1038/s41556-020-0561-5
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DOI: https://doi.org/10.1038/s41556-020-0561-5
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