MEMBRANE TRAFFICKING

ESCRTs cut some slack

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In this issue of Nature Cell Biology, Mercier et al. show that acute changes in membrane tension may be a physiological trigger for ESCRT assembly, which drives membrane scission, luminal vesicle budding, and a wide array of other membrane remodelling events throughout the cell.

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Fig. 1: ESCRT-III drives many membrane-modelling events throughout the cell, including the completion and scission of intralumenal vesicles that bud from the limiting membrane of early endosomes, pictured here.

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Correspondence to Robert C. Piper.

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Piper, R.C. ESCRTs cut some slack. Nat Cell Biol 22, 915–916 (2020). https://doi.org/10.1038/s41556-020-0557-1

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