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Cancer

Starve a cold, and perhaps a cancer

Nature Cell Biology volume 22, pages 755–757 (2020)Cite this article

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Stem cells tightly link their metabolism to cell fate decisions; however, how cancers co-opt and bypass metabolic pathways for growth advantage remains unclear. New evidence in this issue highlights how cancer stem cells avoid epigenetically driven differentiation by shutting down endogenous serine synthesis and becoming serine auxotrophs.

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Fig. 1: Differential serine metabolic pathways are dependent on epidermal cellular states.

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  1. Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA

    Daniel Haensel & Anthony E. Oro

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  1. Daniel Haensel
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  2. Anthony E. Oro
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Correspondence to Anthony E. Oro.

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The authors declare no competing interests.

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Haensel, D., Oro, A.E. Starve a cold, and perhaps a cancer. Nat Cell Biol 22, 755–757 (2020). https://doi.org/10.1038/s41556-020-0543-7

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