Epigenetics

In and out from senescence

Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.

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Fig. 1: Activator Protein 1 (AP-1) acts as pioneer transcription factor during the senescence transition.

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Correspondence to Andrea Alimonti.

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Zumerle, S., Alimonti, A. In and out from senescence. Nat Cell Biol 22, 753–754 (2020). https://doi.org/10.1038/s41556-020-0540-x

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