In and out from senescence

Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.

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Fig. 1: Activator Protein 1 (AP-1) acts as pioneer transcription factor during the senescence transition.


  1. 1.

    Mayran, A. & Drouin, J. J. Biol. Chem. 293, 13795–13804 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    Martínez-Zamudio, R. I. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0529-5 (2020).

  3. 3.

    Hernandez-Segura, A., Nehme, J. & Demaria, M. Trends Cell Biol. 28, 436–453 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Yang, N. & Sen, P. Aging (Albany N.Y.) 10, 3590–3609 (2018).

    CAS  Google Scholar 

  5. 5.

    Tasdemir, N. et al. Cancer Discov. 6, 612–629 (2016).

    CAS  Article  Google Scholar 

  6. 6.

    Sen, P. et al. Mol. Cell 73, 684–698.e8 (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Eferl, R. & Wagner, E. F. Nat. Rev. Cancer 3, 859–868 (2003).

    CAS  Article  Google Scholar 

  8. 8.

    Coppé, J.-P., Desprez, P.-Y., Krtolica, A. & Campisi, J. Annu. Rev. Pathol. 5, 99–118 (2010).

    Article  Google Scholar 

  9. 9.

    Demaria, M. et al. Cancer Discov. 7, 165–176 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Baker, D. J. et al. Nature 530, 184–189 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Lee, S. & Schmitt, C. A. Nat. Cell Biol. 21, 94–101 (2019).

    CAS  Article  Google Scholar 

  12. 12.

    Ocampo, A. et al. Cell 167, 1719–1733.e12 (2016).

    CAS  Article  Google Scholar 

  13. 13.

    Wang, L. et al. Cell Reports 21, 773–783 (2017).

    CAS  Article  Google Scholar 

  14. 14.

    Sun, Y., Coppé, J.-P. & Lam, E. W.-F. Trends Mol. Med. 24, 871–885 (2018).

    CAS  Article  Google Scholar 

  15. 15.

    Ye, N., Ding, Y., Wild, C., Shen, Q. & Zhou, J. J. Med. Chem. 57, 6930–6948 (2014).

    CAS  Article  Google Scholar 

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Correspondence to Andrea Alimonti.

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Zumerle, S., Alimonti, A. In and out from senescence. Nat Cell Biol 22, 753–754 (2020). https://doi.org/10.1038/s41556-020-0540-x

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