The transcription factor oestrogen receptor alpha (ERα) has long been targeted for therapeutic benefit in cancer, but drug resistance can emerge through a multitude of mechanisms. A study now reveals how the ERα cistrome can become reprogrammed to confer resistance to tamoxifen in breast cancer.
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C.R.V. has received funding from Boehringer Ingelheim and Syros Pharmaceuticals and is an advisor to KSQ Therapeutics.
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Wu, X.S., Vakoc, C.R. A pliable ERα cistrome evades therapy. Nat Cell Biol 22, 619–620 (2020). https://doi.org/10.1038/s41556-020-0528-6
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DOI: https://doi.org/10.1038/s41556-020-0528-6
