STEM CELLS

Bridging naïve and primed pluripotency

Pluripotent cells generate all types of cells in the body and have largely been classified dichotomously into two types: naïve and primed. Arguing against a binary classification system, a study now discovers a unique transition state between naïve and primed pluripotency and describes the signals that control this transition.

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Fig. 1: A continuum of pluripotent states in the early mouse embryo.

References

  1. 1.

    Loh, K. M., Lim, B. & Ang, L. T. Physiol. Rev. 95, 245–295 (2015).

    Article  Google Scholar 

  2. 2.

    Nichols, J. & Smith, A. Cell Stem Cell 4, 487–492 (2009).

    CAS  Article  Google Scholar 

  3. 3.

    Brons, I. G. M. et al. Nature 448, 191–195 (2007).

    CAS  Article  Google Scholar 

  4. 4.

    Tesar, P. J. et al. Nature 448, 196–199 (2007).

    CAS  Article  Google Scholar 

  5. 5.

    Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S. & Saitou, M. Cell 146, 519–532 (2011).

    CAS  Article  Google Scholar 

  6. 6.

    Neagu, A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-020-0508-x (2020).

  7. 7.

    Cornacchia, D. et al. Cell Stem Cell 25, 120–136.e10 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Du, P. et al. Cell Stem Cell 22, 851–864.e5 (2018).

    CAS  Article  Google Scholar 

  9. 9.

    Kalkan, T. et al. Development 144, 1221–1234 (2017).

    CAS  Article  Google Scholar 

  10. 10.

    Bedzhov, I. & Zernicka-Goetz, M. Cell 156, 1032–1044 (2014).

    CAS  Article  Google Scholar 

  11. 11.

    Pelton, T. A., Sharma, S., Schulz, T. C., Rathjen, J. & Rathjen, P. D. J. Cell Sci. 115, 329–339 (2002).

    CAS  PubMed  Google Scholar 

  12. 12.

    Zheng, Y. et al. Nature 573, 421–425 (2019).

    CAS  Article  Google Scholar 

  13. 13.

    Clevers, H., Loh, K. M. & Nusse, R. Science 346, 1248012 (2014).

    Article  Google Scholar 

  14. 14.

    Loh, K. M. et al. Cell 166, 451–467 (2016).

    CAS  Article  Google Scholar 

  15. 15.

    Varol, C., Mildner, A. & Jung, S. Annu. Rev. Immunol. 33, 643–675 (2015).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Kyle M. Loh.

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Dundes, C.E., Loh, K.M. Bridging naïve and primed pluripotency. Nat Cell Biol 22, 513–515 (2020). https://doi.org/10.1038/s41556-020-0509-9

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