Active transport along microtubules by molecular motors is a crucial cellular process that is disrupted in human diseases. Single-molecule studies from three independent groups reveal a new molecular mechanism for how cells control the activity of the complex microtubule motor cytoplasmic dynein via the neurodevelopmental protein LIS1.
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McKenney, R.J. LIS1 cracks open dynein. Nat Cell Biol 22, 515–517 (2020). https://doi.org/10.1038/s41556-020-0500-5
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DOI: https://doi.org/10.1038/s41556-020-0500-5