EPIGENETICS

Setting the chromatin stage in oocytes

Post-translational histone modifications are important regulators of nuclear reprogramming. A study now reveals that histone lysine demethylase KDM4A-mediated H3K9me3 demethylation in mammalian oocytes is essential for zygotic genome activation and preimplantation development.

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Fig. 1: KDM4A prevents the accumulation of H3K9me3 in oocytes and counteracts transcriptional silencing in the zygote.

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Correspondence to Matthew C. Lorincz.

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Brind’Amour, J., Lorincz, M.C. Setting the chromatin stage in oocytes. Nat Cell Biol 22, 355–357 (2020). https://doi.org/10.1038/s41556-020-0499-7

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