SIGNALLING

YAP/TAZ phase separation for transcription

YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enhancers.

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Fig. 1: Depiction of the findings from Cai et al.3 and Lu et al.4.

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Correspondence to Kun-Liang Guan.

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K.L.G. is a cofounder of and has equity interest in Vivace Therapeutics.

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Franklin, J.M., Guan, K. YAP/TAZ phase separation for transcription. Nat Cell Biol 22, 357–358 (2020). https://doi.org/10.1038/s41556-020-0498-8

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