YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enhancers.
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K.L.G. is a cofounder of and has equity interest in Vivace Therapeutics.
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Franklin, J.M., Guan, KL. YAP/TAZ phase separation for transcription. Nat Cell Biol 22, 357–358 (2020). https://doi.org/10.1038/s41556-020-0498-8
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DOI: https://doi.org/10.1038/s41556-020-0498-8
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