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Unlocking the door for ERAD

Misfolded proteins in the endoplasmic reticulum (ER) are returned to the cytosol and destroyed by a process known as ER-associated degradation (ERAD). Hrd1 has been implicated as the channel that mediates the transport of ERAD substrates to the cytosol. A study demonstrates that Hrd1 is gated by autoubiquitination and a soluble ERAD substrate.

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Fig. 1: The Hrd1 complex and the schematic for Hrd1-dependent retrotranslocation of ERAD substrates.

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Correspondence to Jeffrey L. Brodsky.

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Betegon, M., Brodsky, J.L. Unlocking the door for ERAD. Nat Cell Biol 22, 263–265 (2020). https://doi.org/10.1038/s41556-020-0476-1

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