Understanding the metabolic rewiring of pancreatic ductal adenocarcinoma is an emerging strategy for identifying cancer-associated liabilities and improving treatment. A new study now elucidates the function of the transaminase BCAT2 in the early stages of tumor development, providing insights that could stimulate novel therapeutic strategies.
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O.D.K.M. contributed to the CRUK Cancer Research Technology’s filing of UK Patent Application no. 1609441.9, and is a founder and shareholder of Faeth Therapeutics.
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Falcone, M., Maddocks, O.D.K. The KRAS-BCAA-BCAT2 axis in PDAC development. Nat Cell Biol 22, 139–140 (2020). https://doi.org/10.1038/s41556-020-0467-2
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DOI: https://doi.org/10.1038/s41556-020-0467-2
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Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
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