The KRAS-BCAA-BCAT2 axis in PDAC development

Understanding the metabolic rewiring of pancreatic ductal adenocarcinoma is an emerging strategy for identifying cancer-associated liabilities and improving treatment. A new study now elucidates the function of the transaminase BCAT2 in the early stages of tumor development, providing insights that could stimulate novel therapeutic strategies.

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Fig. 1: KRAS mutation boosts BCAA metabolism, which promotes PanIN development.


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Correspondence to Oliver D. K. Maddocks.

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Competing interests

O.D.K.M. contributed to the CRUK Cancer Research Technology’s filing of UK Patent Application no. 1609441.9, and is a founder and shareholder of Faeth Therapeutics.

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Falcone, M., Maddocks, O.D.K. The KRAS-BCAA-BCAT2 axis in PDAC development. Nat Cell Biol 22, 139–140 (2020).

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