Ribosome-guided piRNA production

The ribosome decodes messenger RNAs and constructs proteins based on the genetic blueprint. Ribosomes also associate with non-coding RNAs, such as PIWI-interacting RNA (piRNA) precursors, during the meiotic pachytene stage. Intriguingly, the ribosome mediates pachytene piRNA biogenesis by guiding endonucleolytic cleavage of piRNA precursors.

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Fig. 1: Ribosome-guided pachytene piRNA biogenesis.


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Correspondence to Shu-Bing Qian.

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Mao, Y., Qian, SB. Ribosome-guided piRNA production. Nat Cell Biol 22, 141–142 (2020). https://doi.org/10.1038/s41556-020-0464-5

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