Alterations in nuclear shape are present in human diseases and ageing. A compromised nuclear lamina is molecularly interlinked to altered chromatin functions and genomic instability. Whether these alterations are a cause or a consequence of the pathological state are important questions in biology. Here, we summarize the roles of nuclear envelope components in chromatin organization, phase separation and transcriptional and epigenetic regulation. Examining these functions in healthy backgrounds will guide us towards a better understanding of pathological alterations.
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We are thankful to M. Shvedunova, M. Samata, M. Wiese, I. Grządzielewska and A. Apostolidou for carefully reading and commenting on the manuscript. Research in the Akhtar Lab is funded by the Max Planck Society and the Deutsche Forschungsgemeinschaft (DFG) through collaborative research grants SFB 992, SFB 1381, SFB 1425 and the CIBSS Cluster of Excellence (EXC-2189).
The authors declare no competing interests.
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Karoutas, A., Akhtar, A. Functional mechanisms and abnormalities of the nuclear lamina. Nat Cell Biol 23, 116–126 (2021). https://doi.org/10.1038/s41556-020-00630-5
Acta Neuropathologica Communications (2021)