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NON-CODING RNA

H19 lncRNA to dystrophin’s rescue

Nature Cell Biology volume 22, pages 1289–1290 (2020)Cite this article

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There are many challenges in finding an effective, long-lasting and universal cure for the whole cohort of patients with Duchenne muscular dystrophy (DMD). The discovery of H19 lncRNA as a stabiliser of dystrophin may prove to be the missing link to the success of various rescue therapies proposed for treating DMD.

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Fig. 1: The lncRNA H19 protects dystrophin from degradation.

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Authors and Affiliations

  1. Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Morten Ritso & Michael A. Rudnicki

  2. Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada

    Morten Ritso & Michael A. Rudnicki

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  1. Morten Ritso
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  2. Michael A. Rudnicki
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Correspondence to Michael A. Rudnicki.

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Competing interests

M.A.R. is a Founder and CSO of Satellos Bioscience. M.R. declares no competing interests.

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Ritso, M., Rudnicki, M.A. H19 lncRNA to dystrophin’s rescue. Nat Cell Biol 22, 1289–1290 (2020). https://doi.org/10.1038/s41556-020-00598-2

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