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AUTOPHAGY

Autophagy goes nuclear

Sirtuins are highly conserved enzymes with key roles in life extension in multiple organisms. A study now describes selective autophagic degradation of nuclear SIRT1 in senescent cells. These observations suggest that blocking sirtuin degradation could be a potential approach for anti-ageing therapies.

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Fig. 1: Sirtuin-1 lysosomal degradation in senescence/ageing.

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Correspondence to Toren Finkel.

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Tan, J.X., Finkel, T. Autophagy goes nuclear. Nat Cell Biol 22, 1159–1161 (2020). https://doi.org/10.1038/s41556-020-00587-5

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