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AUTOPHAGY

Autophagy goes nuclear

Nature Cell Biology volume 22, pages 1159–1161 (2020)Cite this article

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Sirtuins are highly conserved enzymes with key roles in life extension in multiple organisms. A study now describes selective autophagic degradation of nuclear SIRT1 in senescent cells. These observations suggest that blocking sirtuin degradation could be a potential approach for anti-ageing therapies.

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Fig. 1: Sirtuin-1 lysosomal degradation in senescence/ageing.

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Authors and Affiliations

  1. Aging Institute, University of Pittsburgh School of Medicine/University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    Jay X. Tan & Toren Finkel

  2. Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jay X. Tan

  3. Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Toren Finkel

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  1. Jay X. Tan
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  2. Toren Finkel
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Correspondence to Toren Finkel.

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The authors declare no competing interests.

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Tan, J.X., Finkel, T. Autophagy goes nuclear. Nat Cell Biol 22, 1159–1161 (2020). https://doi.org/10.1038/s41556-020-00587-5

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