STEM CELLS

ERADicating stem cells from their niche

Protein homeostasis preserves stem cell function, but the underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopoietic stem cell function through niche interaction.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: SEL1L promotes HSC maintenance, function, and niche interactions by maintaining quality control and surface expression of MPL.

References

  1. 1.

    Chua, B. A. & Signer, R. A. J. Curr. Opin. Hematol. 27, 254–263 (2020).

    Article  Google Scholar 

  2. 2.

    Signer, R. A., Magee, J. A., Salic, A. & Morrison, S. J. Nature 509, 49–54 (2014).

    CAS  Article  Google Scholar 

  3. 3.

    Hidalgo San Jose, L. & Signer, R. A. J. Nat. Protoc. 14, 441–460 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Xu, L. et al. Nat. Cell Biol. 22, https://doi.org/10.1038/s41556-020-00581-x (2020).

  5. 5.

    Brodsky, J. L. Cell 151, 1163–1167 (2012).

    CAS  Article  Google Scholar 

  6. 6.

    Mueller, B., Lilley, B. N. & Ploegh, H. L. J. Cell Biol. 175, 261–270 (2006).

    CAS  Article  Google Scholar 

  7. 7.

    van Galen, P. et al. Cell Rep. 25, 1109–1117.e5 (2018).

    Article  Google Scholar 

  8. 8.

    Chapple, R. H. et al. eLife 7, e31159 (2018).

    Article  Google Scholar 

  9. 9.

    Liu, L. et al. Nat. Cell Biol. 21, 328–337 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Crane, G. M., Jeffery, E. & Morrison, S. J. Nat. Rev. Immunol. 17, 573–590 (2017).

    CAS  Article  Google Scholar 

  11. 11.

    Liu, L. et al. Preprint at bioRxiv https://doi.org/10.1101/709964 (2019).

  12. 12.

    Yoshihara, H. et al. Cell Stem Cell 1, 685–697 (2007).

    CAS  Article  Google Scholar 

  13. 13.

    Methia, N., Louache, F., Vainchenker, W. & Wendling, F. Blood 82, 1395–1401 (1993).

    CAS  Article  Google Scholar 

  14. 14.

    Gekas, C. & Graf, T. Blood 121, 4463–4472 (2013).

    CAS  Article  Google Scholar 

  15. 15.

    Rabe, J. L. et al. Exp. Hematol. 81, 1–15.e6 (2020).

    CAS  Article  Google Scholar 

  16. 16.

    van Galen, P. et al. Nature 510, 268–272 (2014).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Robert A. J. Signer.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lam, K., Signer, R.A.J. ERADicating stem cells from their niche. Nat Cell Biol 22, 1155–1157 (2020). https://doi.org/10.1038/s41556-020-00585-7

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing