ERADicating stem cells from their niche

Protein homeostasis preserves stem cell function, but the underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopoietic stem cell function through niche interaction.

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Fig. 1: SEL1L promotes HSC maintenance, function, and niche interactions by maintaining quality control and surface expression of MPL.


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Correspondence to Robert A. J. Signer.

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Lam, K., Signer, R.A.J. ERADicating stem cells from their niche. Nat Cell Biol 22, 1155–1157 (2020).

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