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STEM CELLS

ERADicating stem cells from their niche

Nature Cell Biology volume 22, pages 1155–1157 (2020)Cite this article

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Protein homeostasis preserves stem cell function, but the underlying mechanisms are largely unknown. A study reveals that protein quality control mediated by the endoplasmic reticulum-associated degradation pathway ensures proper expression of MPL, a key cell surface receptor that promotes haematopoietic stem cell function through niche interaction.

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Fig. 1: SEL1L promotes HSC maintenance, function, and niche interactions by maintaining quality control and surface expression of MPL.

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Authors and Affiliations

  1. Division of Hematology and Oncology, University of California San Diego, La Jolla, CA, USA

    Kentson Lam

  2. Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA

    Kentson Lam & Robert A. J. Signer

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  1. Kentson Lam
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  2. Robert A. J. Signer
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Correspondence to Robert A. J. Signer.

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The authors declare no competing interests.

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Lam, K., Signer, R.A.J. ERADicating stem cells from their niche. Nat Cell Biol 22, 1155–1157 (2020). https://doi.org/10.1038/s41556-020-00585-7

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