MEMBRANE TRAFFICKING

Clock regulation of protein secretion

The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: The molecular clock drives circadian gene expression of clock-controlled genes.
Fig. 2: Clock control of the protein secretory pathway.

References

  1. 1.

    Takahashi, J. S., Hong, H. K., Ko, C. H. & McDearmon, E. L. Nat. Rev. Genet. 9, 764–775 (2008).

    CAS  Article  Google Scholar 

  2. 2.

    Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E. & Hogenesch, J. B. Proc. Natl. Acad. Sci. USA 111, 16219–16224 (2014).

    CAS  Article  Google Scholar 

  3. 3.

    Chang, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0441-z (2020).

  4. 4.

    Shoulders, M. D. & Raines, R. T. Annu. Rev. Biochem. 78, 929–958 (2009).

    CAS  Article  Google Scholar 

  5. 5.

    Wynn, T. A. J. Clin. Invest. 117, 524–529 (2007).

    CAS  Article  Google Scholar 

  6. 6.

    Woo, S. L. et al. Connect. Tissue Res. 7, 177–183 (1980).

    CAS  Article  Google Scholar 

  7. 7.

    Yeung, C. Y. et al. Sci. Rep. 4, 5183 (2014).

    CAS  Article  Google Scholar 

  8. 8.

    Janich, P., Arpat, A. B., Castelo-Szekely, V., Lopes, M. & Gatfield, D. Genome Res. 25, 1848–1859 (2015).

    CAS  Article  Google Scholar 

  9. 9.

    Rapoport, T. A. Nature 450, 663–669 (2007).

    CAS  Article  Google Scholar 

  10. 10.

    Malhotra, V. & Erlmann, P. Annu. Rev. Cell Dev. Biol. 31, 109–124 (2015).

    CAS  Article  Google Scholar 

  11. 11.

    Cancino, J. et al. Dev. Cell 30, 280–294 (2014).

    CAS  Article  Google Scholar 

  12. 12.

    Banushi, B. et al. Nat. Commun. 7, 12111 (2016).

    CAS  Article  Google Scholar 

  13. 13.

    Novinec, M. & Lenarčič, B. Biol. Chem. 394, 1163–1179 (2013).

    CAS  Article  Google Scholar 

  14. 14.

    Hirota, T. et al. Science 337, 1094–1097 (2012).

    CAS  Article  Google Scholar 

  15. 15.

    Solt, L. A. et al. Nature 485, 62–68 (2012).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Thomas P. Burris.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Burris, T.P. Clock regulation of protein secretion. Nat Cell Biol 22, 1–3 (2020). https://doi.org/10.1038/s41556-019-0449-4

Download citation

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing