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Clock regulation of protein secretion

The molecular clock regulates the rhythmic transcription of myriad genes, leading to a circadian pattern of expression of the encoded proteins. A study demonstrates circadian regulation of expression of components of the protein secretory pathway, providing a mechanism to generate circadian patterns of secreted protein expression.

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Fig. 1: The molecular clock drives circadian gene expression of clock-controlled genes.
Fig. 2: Clock control of the protein secretory pathway.


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Correspondence to Thomas P. Burris.

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Burris, T.P. Clock regulation of protein secretion. Nat Cell Biol 22, 1–3 (2020).

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