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Endfoot regrowth for neural stem cell renewal

Tangential expansion of neural stem cells in the mammalian neocortex increases the number of cortical columns. A new study shows that neural stem cells that become detached from the apical surface during division regenerate an apical endfoot to ensure tangential expansion in the early stage but later lose this ability when radial expansion occurs.

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Fig. 1: Post-mitotic structural dynamics of a basal process-inheriting daughter cell of ventricular (apical) radial glial cells.

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Correspondence to Yukiko Gotoh.

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Tsuboi, M., Gotoh, Y. Endfoot regrowth for neural stem cell renewal. Nat Cell Biol 22, 3–5 (2020). https://doi.org/10.1038/s41556-019-0448-5

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