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Unraveling bone marrow architecture

Different types of stromal cells in the bone marrow associate to form niches that support differentiating blood cells and ensure lifelong production of all major blood lineages. A study now combines single-cell and spatial transcriptomics with imaging to infer the cellular composition and spatial architecture of specific niches.

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Fig. 1: Scheme showing the experimental workflow used by Baccin, Al-Sabah, Velten et al. to dissect the cellular architecture of the bone marrow (BM) microenvironment.


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Correspondence to H. Leighton Grimes.

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Lucas, D., Salomonis, N. & Grimes, H.L. Unraveling bone marrow architecture. Nat Cell Biol 22, 5–6 (2020).

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