Different types of stromal cells in the bone marrow associate to form niches that support differentiating blood cells and ensure lifelong production of all major blood lineages. A study now combines single-cell and spatial transcriptomics with imaging to infer the cellular composition and spatial architecture of specific niches.
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Lucas, D., Salomonis, N. & Grimes, H.L. Unraveling bone marrow architecture. Nat Cell Biol 22, 5–6 (2020). https://doi.org/10.1038/s41556-019-0447-6
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DOI: https://doi.org/10.1038/s41556-019-0447-6