Oxidation of CLOCK boosts circadian rhythms

In mammals, a circadian timing system composed of a master clock in the brain’s suprachiasmatic nucleus and oscillators in peripheral organs drives daily rhythms of behavior and physiology. A study now reveals that the periodic oxidation of the CLOCK protein enhances the amplitude of cyclic gene expression and affects the daily rhythms of behavior.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: The circadian accumulation of H2O2 bolsters circadian gene expression by facilitating CLOCK-BMAL1 heterodimerization.


  1. 1.

    Dibner, C., Schibler, U. & Albrecht, U. Annu. Rev. Physiol. 72, 517–549 (2010).

    CAS  Article  Google Scholar 

  2. 2.

    Aryal, R. P. et al. Mol. Cell 67, 770–782.e6 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Peek, C. B. et al. Methods Enzymol. 552, 165–184 (2015).

    CAS  Article  Google Scholar 

  4. 4.

    Adamovich, Y. et al. Cell Metab. 29, 1092–1103.e3 (2019).

    CAS  Article  Google Scholar 

  5. 5.

    Pei, J. et al. Nat. Cell Biol. (2019).

  6. 6.

    Manella, G. & Asher, G. Front. Endocrinol. 7, 162 (2016).

    Article  Google Scholar 

  7. 7.

    Ding, C. et al. Proc. Natl. Acad. Sci. USA 110, 6771–6776 (2013).

    CAS  Article  Google Scholar 

  8. 8.

    Nelson, K. J. et al. Methods Enzymol. 473, 95–115 (2010).

    CAS  Article  Google Scholar 

  9. 9.

    Kim, J. R., Yoon, H. W., Kwon, K. S., Lee, S. R. & Rhee, S. G. Anal. Biochem. 283, 214–221 (2000).

    CAS  Article  Google Scholar 

  10. 10.

    Huang, N. et al. Science 337, 189–194 (2012).

    CAS  Article  Google Scholar 

  11. 11.

    Giorgio, M. et al. Cell 122, 221–233 (2005).

    CAS  Article  Google Scholar 

  12. 12.

    Yoo, S. H. et al. Proc. Natl. Acad. Sci. USA 101, 5339–5346 (2004).

    CAS  Article  Google Scholar 

  13. 13.

    O’Neill, J. S. & Reddy, A. B. Nature 469, 498–503 (2011).

    Article  Google Scholar 

  14. 14.

    Cho, C. S., Yoon, H. J., Kim, J. Y., Woo, H. A. & Rhee, S. G. Proc. Natl Acad. Sci. USA 111, 12043–12048 (2014).

    CAS  Article  Google Scholar 

  15. 15.

    Putker, M. et al. Antioxid. Redox Signal. 28, 507–520 (2018).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Ueli Schibler.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schibler, U. Oxidation of CLOCK boosts circadian rhythms. Nat Cell Biol 21, 1464–1465 (2019).

Download citation

Further reading


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing