METABOLISM

Oxidation of CLOCK boosts circadian rhythms

In mammals, a circadian timing system composed of a master clock in the brain’s suprachiasmatic nucleus and oscillators in peripheral organs drives daily rhythms of behavior and physiology. A study now reveals that the periodic oxidation of the CLOCK protein enhances the amplitude of cyclic gene expression and affects the daily rhythms of behavior.

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Fig. 1: The circadian accumulation of H2O2 bolsters circadian gene expression by facilitating CLOCK-BMAL1 heterodimerization.

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Correspondence to Ueli Schibler.

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Schibler, U. Oxidation of CLOCK boosts circadian rhythms. Nat Cell Biol 21, 1464–1465 (2019). https://doi.org/10.1038/s41556-019-0430-2

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