Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

METABOLISM

Oxidation of CLOCK boosts circadian rhythms

In mammals, a circadian timing system composed of a master clock in the brain’s suprachiasmatic nucleus and oscillators in peripheral organs drives daily rhythms of behavior and physiology. A study now reveals that the periodic oxidation of the CLOCK protein enhances the amplitude of cyclic gene expression and affects the daily rhythms of behavior.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The circadian accumulation of H2O2 bolsters circadian gene expression by facilitating CLOCK-BMAL1 heterodimerization.

References

  1. Dibner, C., Schibler, U. & Albrecht, U. Annu. Rev. Physiol. 72, 517–549 (2010).

    Article  CAS  Google Scholar 

  2. Aryal, R. P. et al. Mol. Cell 67, 770–782.e6 (2017).

    Article  CAS  Google Scholar 

  3. Peek, C. B. et al. Methods Enzymol. 552, 165–184 (2015).

    Article  CAS  Google Scholar 

  4. Adamovich, Y. et al. Cell Metab. 29, 1092–1103.e3 (2019).

    Article  CAS  Google Scholar 

  5. Pei, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0420-4 (2019).

  6. Manella, G. & Asher, G. Front. Endocrinol. 7, 162 (2016).

    Article  Google Scholar 

  7. Ding, C. et al. Proc. Natl. Acad. Sci. USA 110, 6771–6776 (2013).

    Article  CAS  Google Scholar 

  8. Nelson, K. J. et al. Methods Enzymol. 473, 95–115 (2010).

    Article  CAS  Google Scholar 

  9. Kim, J. R., Yoon, H. W., Kwon, K. S., Lee, S. R. & Rhee, S. G. Anal. Biochem. 283, 214–221 (2000).

    Article  CAS  Google Scholar 

  10. Huang, N. et al. Science 337, 189–194 (2012).

    Article  CAS  Google Scholar 

  11. Giorgio, M. et al. Cell 122, 221–233 (2005).

    Article  CAS  Google Scholar 

  12. Yoo, S. H. et al. Proc. Natl. Acad. Sci. USA 101, 5339–5346 (2004).

    Article  CAS  Google Scholar 

  13. O’Neill, J. S. & Reddy, A. B. Nature 469, 498–503 (2011).

    Article  Google Scholar 

  14. Cho, C. S., Yoon, H. J., Kim, J. Y., Woo, H. A. & Rhee, S. G. Proc. Natl Acad. Sci. USA 111, 12043–12048 (2014).

    Article  CAS  Google Scholar 

  15. Putker, M. et al. Antioxid. Redox Signal. 28, 507–520 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ueli Schibler.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schibler, U. Oxidation of CLOCK boosts circadian rhythms. Nat Cell Biol 21, 1464–1465 (2019). https://doi.org/10.1038/s41556-019-0430-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-019-0430-2

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing