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Chromatin

A transient absence of SMC-mediated loops after mitosis

After mitosis chromosomes are drastically reshaped. A study now charts the dynamics of this conformational change at high temporal resolution. During the shift from one loop-forming complex (condensin) to another (cohesin), an intermediate chromosome folding state exists in which neither of these complexes are associated with chromatin.

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Fig. 1: Loop organization during the transition from mitosis to interphase.

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Correspondence to Elzo de Wit.

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Liu, N.Q., de Wit, E. A transient absence of SMC-mediated loops after mitosis. Nat Cell Biol 21, 1303–1304 (2019). https://doi.org/10.1038/s41556-019-0421-3

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