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Deciphering cellular heterogeneity of pancreatic tumours

Nature Cell Biology volume 21, pages 1305–1306 (2019)Cite this article

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Pancreatic ductal adenocarcinoma displays high levels of cellular heterogeneity, which is associated with drug resistance and high metastatic rates. A new study shows that tetraspanin CD9 marks PDAC tumour-initiating cells and functions as a regulator of glutamine metabolism.

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Fig. 1: TICs that express high surface levels of CD9 have the ability to initiate PDACs and recapitulate their cellular heterogeneity.

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Authors and Affiliations

  1. Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA

    Xiphias Ge Zhu & Kivanc Birsoy

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  1. Xiphias Ge Zhu
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  2. Kivanc Birsoy
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Correspondence to Kivanc Birsoy.

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The authors declare no competing interests.

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Zhu, X.G., Birsoy, K. Deciphering cellular heterogeneity of pancreatic tumours. Nat Cell Biol 21, 1305–1306 (2019). https://doi.org/10.1038/s41556-019-0419-x

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