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PTEN isoforms with dual and opposing function

PTEN is a phosphatase that functions as a tumour suppressor by antagonizing the PI3K–AKT pathway. However, a study now demonstrates that translational variants of PTEN enable new interactions between PTEN and the COMPASS complex, identifying a new role for PTEN in modifying gene expression via COMPASS-mediated histone H3 lysine 4 methylation.

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Fig. 1: Translational variants of PTEN.

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Acknowledgements

J.T. is supported by the Conquer Cancer Foundation of the American Society of Clinical Oncology, the American Association for Cancer Research, the American Society of Hematology (ASH), the Robert Wood Johnson Foundation, and the NIH/NCI (1K08CA230319-01). O.A.-W. is supported by the Leukemia and Lymphoma Society, NIH/NHLBI (R01 HL128239), NIH/NCI (1 R01 CA201247-01A1), and the Pershing Square Sohn Cancer Research Alliance.

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Correspondence to Omar Abdel-Wahab.

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O.A.-W. has received research funding from H3 Biomedicine, served as a consultant for H3 Biomedicine, Foundation Medicine, Janssen, and Merck, and serves on the scientific advisory board of Envisagenics, Inc.

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Taylor, J., Abdel-Wahab, O. PTEN isoforms with dual and opposing function. Nat Cell Biol 21, 1306–1308 (2019). https://doi.org/10.1038/s41556-019-0405-3

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