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STEM CELLS

Transcription factors make the right contacts

Cell identity is shaped by a complex interplay between transcription factors, enhancers and genome organisation. A study now reveals a dynamic role for the transcription factor KLF4 in directing gene regulatory interactions during pluripotent cell reprogramming, demonstrating that transcription factors can function as chromatin organisers.

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Fig. 1: The transcription factor KLF4 directs enhancer–promoter interactions in mouse pluripotent stem cells.

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Correspondence to Peter J. Rugg-Gunn.

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Rugg-Gunn, P.J. Transcription factors make the right contacts. Nat Cell Biol 21, 1173–1174 (2019). https://doi.org/10.1038/s41556-019-0399-x

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