Cell identity is shaped by a complex interplay between transcription factors, enhancers and genome organisation. A study now reveals a dynamic role for the transcription factor KLF4 in directing gene regulatory interactions during pluripotent cell reprogramming, demonstrating that transcription factors can function as chromatin organisers.
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References
- 1.
Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).
- 2.
Di Giammartino, D. C. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0390-6 (2019).
- 3.
Chronis, C. et al. Cell 168, 442–459.e20 (2017).
- 4.
Whyte, W. A. et al. Cell 153, 307–319 (2013).
- 5.
Phillips-Cremins, J. E. et al. Cell 153, 1281–1295 (2013).
- 6.
Apostolou, E. et al. Cell Stem Cell 12, 699–712 (2013).
- 7.
de Wit, E. et al. Nature 501, 227–231 (2013).
- 8.
Wei, Z. et al. Cell Stem Cell 13, 36–47 (2013).
- 9.
Stadhouders, R. et al. Nat. Genet. 50, 238–249 (2018).
- 10.
Novo, C. L. et al. Cell Rep. 22, 2615–2627 (2018).
- 11.
Mumbach, M. R. et al. Nat. Methods 13, 919–922 (2016).
- 12.
Allahyar, A. et al. Nat. Genet. 50, 1151–1160 (2018).
- 13.
Oudelaar, A. M. et al. Nat. Genet. 50, 1744–1751 (2018).
- 14.
Beagrie, R. A. et al. Nature 543, 519–524 (2017).
- 15.
Fukaya, T., Lim, B. & Levine, M. Cell 166, 358–368 (2016).
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Rugg-Gunn, P.J. Transcription factors make the right contacts. Nat Cell Biol 21, 1173–1174 (2019). https://doi.org/10.1038/s41556-019-0399-x
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