Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Transcription factors make the right contacts

Cell identity is shaped by a complex interplay between transcription factors, enhancers and genome organisation. A study now reveals a dynamic role for the transcription factor KLF4 in directing gene regulatory interactions during pluripotent cell reprogramming, demonstrating that transcription factors can function as chromatin organisers.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: The transcription factor KLF4 directs enhancer–promoter interactions in mouse pluripotent stem cells.


  1. 1.

    Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    CAS  Article  Google Scholar 

  2. 2.

    Di Giammartino, D. C. et al. Nat. Cell Biol. (2019).

  3. 3.

    Chronis, C. et al. Cell 168, 442–459.e20 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Whyte, W. A. et al. Cell 153, 307–319 (2013).

    CAS  Article  Google Scholar 

  5. 5.

    Phillips-Cremins, J. E. et al. Cell 153, 1281–1295 (2013).

    CAS  Article  Google Scholar 

  6. 6.

    Apostolou, E. et al. Cell Stem Cell 12, 699–712 (2013).

    CAS  Article  Google Scholar 

  7. 7.

    de Wit, E. et al. Nature 501, 227–231 (2013).

    Article  Google Scholar 

  8. 8.

    Wei, Z. et al. Cell Stem Cell 13, 36–47 (2013).

    CAS  Article  Google Scholar 

  9. 9.

    Stadhouders, R. et al. Nat. Genet. 50, 238–249 (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Novo, C. L. et al. Cell Rep. 22, 2615–2627 (2018).

    CAS  Article  Google Scholar 

  11. 11.

    Mumbach, M. R. et al. Nat. Methods 13, 919–922 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Allahyar, A. et al. Nat. Genet. 50, 1151–1160 (2018).

    CAS  Article  Google Scholar 

  13. 13.

    Oudelaar, A. M. et al. Nat. Genet. 50, 1744–1751 (2018).

    CAS  Article  Google Scholar 

  14. 14.

    Beagrie, R. A. et al. Nature 543, 519–524 (2017).

    CAS  Article  Google Scholar 

  15. 15.

    Fukaya, T., Lim, B. & Levine, M. Cell 166, 358–368 (2016).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Peter J. Rugg-Gunn.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rugg-Gunn, P.J. Transcription factors make the right contacts. Nat Cell Biol 21, 1173–1174 (2019).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing