CANCER

Tumours pick the path to cancer inflammation

Tumours elicit an immune attack that can stifle their growth, but they can also recruit inflammatory immune cells that suppress this response. A new study identifies distinct immune subtypes of triple-negative breast cancer with two different inflammatory cell types: macrophages or neutrophils. The immune subtype dictates the response to immunotherapy.

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Fig. 1: Three inflammatory microenvironment subtypes to predict sensitivity to immunotherapy.

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Correspondence to Mikala Egeblad.

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Maiorino, L., Egeblad, M. Tumours pick the path to cancer inflammation. Nat Cell Biol 21, 1055–1057 (2019). https://doi.org/10.1038/s41556-019-0386-2

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