Cell Cycle

KIFC3 directs a centrosome cohesive force

Assembly of the mitotic spindle requires timely separation of the centrosomes. Their movement apart is driven by the plus-end-directed kinesin Eg5. A new study demonstrates that the kinesin KIFC3 provides an opposing microtubule-based cohesive force that modulates centrosome separation and ensures accurate chromosome segregation.

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Fig. 1: Antagonistic activities of KIFC3 and Eg5 determine centrosome separation during the assembly of the mitotic spindle.

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Correspondence to Ciaran G. Morrison.

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Morrison, C.G. KIFC3 directs a centrosome cohesive force. Nat Cell Biol 21, 1057–1059 (2019). https://doi.org/10.1038/s41556-019-0385-3

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