Cell Cycle

KIFC3 directs a centrosome cohesive force

Assembly of the mitotic spindle requires timely separation of the centrosomes. Their movement apart is driven by the plus-end-directed kinesin Eg5. A new study demonstrates that the kinesin KIFC3 provides an opposing microtubule-based cohesive force that modulates centrosome separation and ensures accurate chromosome segregation.

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Fig. 1: Antagonistic activities of KIFC3 and Eg5 determine centrosome separation during the assembly of the mitotic spindle.


  1. 1.

    Prosser, S. L. & Pelletier, L. Nat. Rev. Mol. Cell Biol. 18, 187–201 (2017).

    CAS  Article  Google Scholar 

  2. 2.

    Conduit, P. T., Wainman, A. & Raff, J. W. Nat. Rev. Mol. Cell Biol. 16, 611–624 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Bahe, S., Stierhof, Y. D., Wilkinson, C. J., Leiss, F. & Nigg, E. A. J. Cell Biol. 171, 27–33 (2005).

    CAS  Article  Google Scholar 

  4. 4.

    Mayor, T., Stierhof, Y. D., Tanaka, K., Fry, A. M. & Nigg, E. A. J. Cell Biol. 151, 837–846 (2000).

    CAS  Article  Google Scholar 

  5. 5.

    Faragher, A. J. & Fry, A. M. Mol. Biol. Cell 14, 2876–2889 (2003).

    CAS  Article  Google Scholar 

  6. 6.

    Kapitein, L. C. et al. Nature 435, 114–118 (2005).

    CAS  Article  Google Scholar 

  7. 7.

    Hata, S. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0382-6 (2019).

    Article  Google Scholar 

  8. 8.

    Jean, C., Tollon, Y., Raynaud-Messina, B. & Wright, M. Eur. J. Cell Biol. 78, 549–560 (1999).

    CAS  Article  Google Scholar 

  9. 9.

    Panic, M., Hata, S., Neuner, A. & Schiebel, E. PLoS Genet. 11, e1005243 (2015).

    Article  Google Scholar 

  10. 10.

    Mazo, G., Soplop, N., Wang, W. J., Uryu, K. & Tsou, M. F. Dev. Cell 39, 424–437 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Decarreau, J. et al. Nat. Cell Biol. 19, 384–390 (2017).

    CAS  Article  Google Scholar 

  12. 12.

    Mardin, B. R. et al. Nat. Cell Biol. 12, 1166–1176 (2010).

    CAS  Article  Google Scholar 

  13. 13.

    Saunders, W., Lengyel, V. & Hoyt, M. A. Mol. Biol. Cell 8, 1025–1033 (1997).

    CAS  Article  Google Scholar 

  14. 14.

    Floriot, S. et al. Nat. Commun. 6, 6894 (2015).

    CAS  Article  Google Scholar 

  15. 15.

    Remo, A. et al. Mol. Cancer Res. 16, 1385–1395 (2018).

    CAS  Article  Google Scholar 

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Correspondence to Ciaran G. Morrison.

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Morrison, C.G. KIFC3 directs a centrosome cohesive force. Nat Cell Biol 21, 1057–1059 (2019). https://doi.org/10.1038/s41556-019-0385-3

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