CELL MIGRATION

Migrasomes take center stage

Migrasomes are a recently discovered type of extracellular vesicles that are characteristically generated along retraction fibers in migrating cells. Two studies now show how migrasomes are formed and how they function in the physiologically relevant context of the developing zebrafish embryo.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Migration-depended mechanical force triggers migrasome formation.
Fig. 2: Mesendoderm-derived migrasomes regulate clustering of DFCs.

References

  1. 1.

    Perrimon, N., Pitsouli, C. & Shilo, B. Z. Cold Spring Harb. Perspect. Biol. 4, a005975 (2012).

    Article  Google Scholar 

  2. 2.

    Sever, R. & Brugge, J.S. Cold Spring Harb. Perspect. Med. 5, a006098 (2015).

    Article  Google Scholar 

  3. 3.

    Maas, S. L. N., Breakefield, X. O. & Weaver, A. M. Trends Cell Biol. 27, 172–188 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Meldolesi, J. Curr. Biol. 28, R435–R444 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Cruz, L., Romero, J. A. A., Iglesia, R. P. & Lopes, M. H. Front. Cell Dev. Biol. 6, 94 (2018).

    Article  Google Scholar 

  6. 6.

    Tanaka, Y., Okada, Y. & Hirokawa, N. Nature 435, 172–177 (2005).

    CAS  Article  Google Scholar 

  7. 7.

    Ma, L. et al. Cell Res. 25, 24–38 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Huang, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0367-5 (2019).

  9. 9.

    Jiang, D. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0358-6 (2019).

  10. 10.

    Rohde, L. A. & Heisenberg, C. P. Int. Rev. Cytol. 261, 159–192 (2007).

    CAS  Article  Google Scholar 

  11. 11.

    Solnica-Krezel, L. & Sepich, D. S. Annu. Rev. Cell Dev. Biol. 28, 687–717 (2012).

    CAS  Article  Google Scholar 

  12. 12.

    Matsui, T., Ishikawa, H. & Bessho, Y. Front. Cell Dev. Biol. 3, 27 (2015).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Carl-Philipp Heisenberg.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tavano, S., Heisenberg, C. Migrasomes take center stage. Nat Cell Biol 21, 918–920 (2019). https://doi.org/10.1038/s41556-019-0369-3

Download citation

Further reading