Migrasomes take center stage

Migrasomes are a recently discovered type of extracellular vesicles that are characteristically generated along retraction fibers in migrating cells. Two studies now show how migrasomes are formed and how they function in the physiologically relevant context of the developing zebrafish embryo.

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Fig. 1: Migration-depended mechanical force triggers migrasome formation.
Fig. 2: Mesendoderm-derived migrasomes regulate clustering of DFCs.


  1. 1.

    Perrimon, N., Pitsouli, C. & Shilo, B. Z. Cold Spring Harb. Perspect. Biol. 4, a005975 (2012).

    Article  Google Scholar 

  2. 2.

    Sever, R. & Brugge, J.S. Cold Spring Harb. Perspect. Med. 5, a006098 (2015).

    Article  Google Scholar 

  3. 3.

    Maas, S. L. N., Breakefield, X. O. & Weaver, A. M. Trends Cell Biol. 27, 172–188 (2017).

    CAS  Article  Google Scholar 

  4. 4.

    Meldolesi, J. Curr. Biol. 28, R435–R444 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Cruz, L., Romero, J. A. A., Iglesia, R. P. & Lopes, M. H. Front. Cell Dev. Biol. 6, 94 (2018).

    Article  Google Scholar 

  6. 6.

    Tanaka, Y., Okada, Y. & Hirokawa, N. Nature 435, 172–177 (2005).

    CAS  Article  Google Scholar 

  7. 7.

    Ma, L. et al. Cell Res. 25, 24–38 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Huang, Y. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0367-5 (2019).

  9. 9.

    Jiang, D. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0358-6 (2019).

  10. 10.

    Rohde, L. A. & Heisenberg, C. P. Int. Rev. Cytol. 261, 159–192 (2007).

    CAS  Article  Google Scholar 

  11. 11.

    Solnica-Krezel, L. & Sepich, D. S. Annu. Rev. Cell Dev. Biol. 28, 687–717 (2012).

    CAS  Article  Google Scholar 

  12. 12.

    Matsui, T., Ishikawa, H. & Bessho, Y. Front. Cell Dev. Biol. 3, 27 (2015).

    Article  Google Scholar 

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Correspondence to Carl-Philipp Heisenberg.

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Tavano, S., Heisenberg, C. Migrasomes take center stage. Nat Cell Biol 21, 918–920 (2019). https://doi.org/10.1038/s41556-019-0369-3

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