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STEM CELLS

Equal opportunities in stemness

Nature Cell Biology volume 21, pages 921–923 (2019)Cite this article

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Tissue renewal requires proliferative progenitors with long-lasting potential. Designated stem cells within specialized niches are considered to be the primary mechanism for this requirement. Recent studies show that dispersed equipotent progenitors are sufficient to account for fast-paced cellular dynamics in skin oil glands and foetal gut epithelium.

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Fig. 1: Equipotency and designated stem cells as complementary strategies for lineage maintenance.

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Authors and Affiliations

  1. NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA

    Qing Nie & Maksim V. Plikus

  2. Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA

    Qing Nie & Maksim V. Plikus

  3. Department of Mathematics, University of California, Irvine, Irvine, CA, USA

    Qing Nie

  4. Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA

    Qing Nie & Maksim V. Plikus

  5. Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA

    Maksim V. Plikus

Authors
  1. Qing Nie
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  2. Maksim V. Plikus
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Correspondence to Qing Nie or Maksim V. Plikus.

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The authors declare no competing interests.

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Nie, Q., Plikus, M.V. Equal opportunities in stemness. Nat Cell Biol 21, 921–923 (2019). https://doi.org/10.1038/s41556-019-0366-6

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