Adapting to cell stress from inside and out


The ability of cancer cells to adapt to external and internal stresses is critical for tumourigenesis. A new study now shows that the integrated stress response is critical for tumour cell adaptation to stress induced by c-MYC activation, providing mechanistic insights into tumour responses to intrinsic stresses with implications for cancer therapies.

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Fig. 1: The integrated stress response (ISR) is activated by both intrinsic and extrinsic stresses in human cancer.


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Correspondence to Ronald C. Wek.

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Competing interests

K.A.S. is a consultant for and receives research support from HiberCell, Inc. R.C.W. has research support from Eli Lilly and Company.

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Staschke, K.A., Wek, R.C. Adapting to cell stress from inside and out. Nat Cell Biol 21, 799–800 (2019).

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