CELL DEATH

Parkin inhibits necroptosis to prevent cancer

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Loss-of-function mutations in the ubiquitin ligase Parkin are a cause of Parkinson’s disease. Parkin also has tumour-suppressor activity, although how Parkin prevents cancer is unclear. Unexpectedly, Parkin is found to suppress cancer by inhibiting an inflammatory type of cell death called necroptosis.

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Fig. 1: Parkin inhibits necroptosis to prevent inflammation-induced cancer.

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Correspondence to Stephen W. G. Tait.

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