Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

ORGANELLES

IRE1α modulates ER and mitochondria crosstalk

Nature Cell Biology volume 21, pages 667–668 (2019)Cite this article

Subjects

A Publisher Correction to this article was published on 13 September 2019

This article has been updated

IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A novel role of IRE1α in regulating InsP3R in MAMs.

Change history

  • 13 September 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

References

  1. Depaoli, M. R., Hay, J. C., Graier, W. F. & Malli, R. Biol. Rev. Camb. Philos. Soc. 94, 610–628 (2019).

    Article  Google Scholar 

  2. Bravo, R. et al. Int. Rev. Cell Mol. Biol. 301, 215–290 (2013).

    Article  CAS  Google Scholar 

  3. Adams, C. J., Kopp, M. C., Larburu, N., Nowak, P. R. & Ali, M. M. U. Front. Mol. Biosci. 6, 11 (2019).

    Article  CAS  Google Scholar 

  4. Carreras-Sureda, A. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0329-y (2019).

    Article  CAS  Google Scholar 

  5. Vance, J. E. Biochim. Biophys. Acta 1841, 595–609 (2014).

    Article  CAS  Google Scholar 

  6. Hollien, J. & Weissman, J. S. Science 313, 104–107 (2006).

    Article  CAS  Google Scholar 

  7. Sundaram, A., Plumb, R., Appathurai, S. & Mariappan, M. eLife 6, e27187 (2017).

    Article  Google Scholar 

  8. Prole, D. L. & Taylor, C. W. J. Physiol. (Lond.) 594, 2849–2866 (2016).

    Article  CAS  Google Scholar 

  9. McCormack, J. G. & Denton, R. M. Biochem. J. 218, 235–247 (1984).

    Article  CAS  Google Scholar 

  10. Klec, C. et al. Cell Physiology Biochem 52, 57–75 (2019).

    Article  Google Scholar 

  11. Klein, M.-C. et al. Nat. Commun. 9, 3489 (2018).

    Article  Google Scholar 

  12. Gottschalk, B., Klec, C., Waldeck-Weiermair, M., Malli, R. & Graier, W. F. Pflugers Arch. 470, 1193–1203 (2018).

    Article  CAS  Google Scholar 

  13. Pinton, P. Cell Death Dis. 9, 413 (2018).

    Article  Google Scholar 

  14. Cárdenas, C. et al. Cell Rep. 14, 2313–2324 (2016).

    Article  Google Scholar 

  15. Madreiter-Sokolowski, C. T. et al. Redox Biol. 20, 458–466 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria

    Roland Malli & Wolfgang F. Graier

Authors
  1. Roland Malli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wolfgang F. Graier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wolfgang F. Graier.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Malli, R., Graier, W.F. IRE1α modulates ER and mitochondria crosstalk. Nat Cell Biol 21, 667–668 (2019). https://doi.org/10.1038/s41556-019-0338-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-019-0338-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing