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IRE1α modulates ER and mitochondria crosstalk

A Publisher Correction to this article was published on 13 September 2019

This article has been updated

IRE1α is an endoplasmic reticulum (ER) transmembrane protein known for a crucial role in regulating the unfolding protein response. A study now shows that IRE1α interacts with the main ER Ca2+ channel InsP3Rs and facilitates the transfer of Ca2+ from the ER into mitochondria, thus driving cellular metabolism.

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Fig. 1: A novel role of IRE1α in regulating InsP3R in MAMs.

Change history

  • 13 September 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.


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Correspondence to Wolfgang F. Graier.

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Malli, R., Graier, W.F. IRE1α modulates ER and mitochondria crosstalk. Nat Cell Biol 21, 667–668 (2019).

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