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CELL CYCLE

Centromere maintenance during DNA replication

Nature Cell Biology volume 21, pages 669–671 (2019)Cite this article

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Centromere identity must be maintained through multiple generations. A new study reveals a Constitutive Centromere-Associated Network (CCAN)-dependent retention of CENP-A, a key epigenetic mark for centromeres, in centromeres during DNA replication and a replication-dependent error correction to eliminate ectopic CENP-A in chromosome arms.

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Fig. 1: Centromeric CENP-A retention and ectopic CENP-A elimination during DNA replication.

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Authors and Affiliations

  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

    Masatoshi Hara & Tatsuo Fukagawa

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  1. Masatoshi Hara
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  2. Tatsuo Fukagawa
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Correspondence to Masatoshi Hara or Tatsuo Fukagawa.

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The authors declare no competing interests.

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Hara, M., Fukagawa, T. Centromere maintenance during DNA replication. Nat Cell Biol 21, 669–671 (2019). https://doi.org/10.1038/s41556-019-0335-0

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