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STEM CELLS

Yap in regeneration and symmetry breaking

Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of intestinal regeneration and tissue organization: transient expansion of a rare cell type after damage in vivo and Notch–Dll activation for symmetry breaking in organoid development.

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Fig. 1: Yap activation is crucial for intestinal regenerative responses and organoid symmetry breaking.

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Correspondence to Vivian S. W. Li.

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Li, V.S.W. Yap in regeneration and symmetry breaking. Nat Cell Biol 21, 665–667 (2019). https://doi.org/10.1038/s41556-019-0334-1

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