Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Yap in regeneration and symmetry breaking

Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of intestinal regeneration and tissue organization: transient expansion of a rare cell type after damage in vivo and Notch–Dll activation for symmetry breaking in organoid development.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Fig. 1: Yap activation is crucial for intestinal regenerative responses and organoid symmetry breaking.


  1. 1.

    Barker, N. et al. Nature 449, 1003–1007 (2007).

    CAS  Article  Google Scholar 

  2. 2.

    Sato, T. et al. Nature 459, 262–265 (2009).

    CAS  Article  Google Scholar 

  3. 3.

    Beumer, J. & Clevers, H. Development 143, 3639–3649 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Gregorieff, A., Liu, Y., Inanlou, M. R., Khomchuk, Y. & Wrana, J. L. Nature 526, 715–718 (2015).

    CAS  Article  Google Scholar 

  5. 5.

    Ayyaz, A. et al. Nature (2019).

    CAS  Article  Google Scholar 

  6. 6.

    Serra, D. et al. Nature (2019).

    CAS  Article  Google Scholar 

  7. 7.

    Criswell, T. et al. J. Biol. Chem. 280, 14212–14221 (2005).

    CAS  Article  Google Scholar 

  8. 8.

    Azzolin, L. et al. Cell 158, 157–170 (2014).

    CAS  Article  Google Scholar 

  9. 9.

    van Es, J. H. et al. Nat. Cell Biol. 14, 1099–1104 (2012).

    Article  Google Scholar 

  10. 10.

    Tetteh, P. W. et al. Cell Stem Cell 18, 203–213 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Tian, H. et al. Nature 478, 255–259 (2011).

    CAS  Article  Google Scholar 

  12. 12.

    Takeda, N. et al. Science 334, 1420–1424 (2011).

    CAS  Article  Google Scholar 

  13. 13.

    Montgomery, R. K. et al. Proc. Natl Acad. Sci. USA 108, 179–184 (2011).

    CAS  Article  Google Scholar 

  14. 14.

    Sato, T. et al. Nature 469, 415–418 (2011).

    CAS  Article  Google Scholar 

  15. 15.

    Totaro, A. et al. Nat. Commun. 8, 15206 (2017).

    CAS  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Vivian S. W. Li.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Li, V.S.W. Yap in regeneration and symmetry breaking. Nat Cell Biol 21, 665–667 (2019).

Download citation


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing