Rag GTPases play a crucial role in mTORC1 activation by promoting its recruitment to the lysosomal surface in a nutrient-dependent manner. A study now identifies a family of lysosomal G-protein-coupled receptors as modulators of Rag GTPases localization and activation, adding one more component to the fast-growing mTOR regulatory network.
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References
Saxton, R. A. & Sabatini, D. M. Cell 168, 960–976 (2017).
Yang, H. et al. Nature 552, 368–373 (2017).
Sancak, Y. et al. Cell 141, 290–303 (2010).
Sancak, Y. et al. Science 320, 1496–1501 (2008).
Gan, L. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0321-6 (2019).
Lawrence, R. E. & Zoncu, R. Nat. Cell Biol. 21, 133–142 (2019).
Lawrence, R. E. et al. Nat. Cell Biol. 20, 1052–1063 (2018).
Shen, K., Sidik, H. & Talbot, W. S. Cell Rep. 14, 547–559 (2016).
Martina, J. A. & Puertollano, R. J. Cell Biol. 200, 475–491 (2013).
Zhang, L. Q. et al. Tumori 104, 330–337 (2018).
Wang, C., Liang, Q., Chen, G., Jing, J. & Wang, S. Biotechnol. Appl. Biochem. 62, 868–873 (2015).
Shao, X. et al. Cell Biol. Int. 39, 418–426 (2015).
Cui, X. et al. Biotechnol. Appl. Biochem. 62, 861–867 (2015).
Du, Y. et al. Biotechnol. Appl. Biochem. 62, 855–860 (2015).
Franco, R., Martínez-Pinilla, E., Navarro, G. & Zamarbide, M. Prog. Neurobiol. 149-150, 21–38 (2017).
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Puertollano, R. GPCRs join the mTORC1 regulatory network. Nat Cell Biol 21, 538–539 (2019). https://doi.org/10.1038/s41556-019-0320-7
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DOI: https://doi.org/10.1038/s41556-019-0320-7