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Membrane trafficking

How membrane physics rules the HIV envelope

Nature Cell Biology volume 21, pages 413–415 (2019)Cite this article

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HIV particles incorporate host membrane proteins into their envelope to evade the immune system and infect other cells. A study now shows that Gag assembly on the host cell membrane produces a raft-like nanodomain favourable for protein partitioning due to a transbilayer coupling mechanism assisted by long saturated chain lipids and cholesterol.

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Fig. 1: Schematic representation of transbilayer coupling during HIV budding.
Fig. 2: Scheme of cellular processes that might require transbilayer coupling (marked in brown).

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Authors and Affiliations

  1. Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, Paris, France

    Joanna Podkalicka & Patricia Bassereau

  2. Sorbonne Université, Paris, France

    Joanna Podkalicka & Patricia Bassereau

  3. Laboratory of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, Wrocław, Poland

    Joanna Podkalicka

Authors
  1. Joanna Podkalicka
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  2. Patricia Bassereau
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Correspondence to Patricia Bassereau.

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The authors declare no competing interests.

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Podkalicka, J., Bassereau, P. How membrane physics rules the HIV envelope. Nat Cell Biol 21, 413–415 (2019). https://doi.org/10.1038/s41556-019-0312-7

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