News & Views | Published:

Development

Endothelial cells revealed as chondroclasts

Osteoclasts are known for their role in bone resorption. A study now shows that a vascular–associated osteoclast subtype at the growth plate also regulates blood vessel growth in bone and is supported by type H endothelial cells. These type H capillaries, in turn, release proteinases that promote cartilage degradation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Zaidi, M. & Iqbal, J. Nat. Med. 22, 460–461 (2016).

  2. 2.

    Zaidi, M. Nat. Med. 13, 791–801 (2007).

  3. 3.

    Sara, G. Nat. Cell Biol.. https://doi.org/10.1038/s41556-019-0304-7 (2019).

  4. 4.

    Ramasamy, S. K. Stem Cells Int. 2017, 5046953 (2017).

  5. 5.

    Ramasamy, S. K. et al. Annu. Rev. Cell Dev. Biol. 32, 649–675 (2016).

  6. 6.

    Iqbal, J. & Zaidi, M. Biochem. Biophys. Res. Commun. 328, 751–755 (2005).

  7. 7.

    Vu, T. H. et al. Cell 93, 411–422 (1998).

  8. 8.

    Aiken, A. & Khokha, R. Biochim. Biophys. Acta 121–132, 2010 (1803).

  9. 9.

    Schenk, R. K., Wiener, J. & Spiro, D. Acta Anat. 69, 1–17 (1968).

  10. 10.

    Maes, C. & Clemens, T. L. Bonekey Rep. 3, 578 (2014).

  11. 11.

    Savostin-Asling, I. & Asling, C. W. Anat. Rec. 183, 373–391 (1975).

  12. 12.

    Rose, B. J. & Kooyman, D. L. Dis. Markers 2016, 4895050 (2016).

  13. 13.

    Ramasamy, S. K. et al. Nat. Commun. 7, 13601 (2016).

  14. 14.

    Alam, A. S. et al. Endocrinology 130, 3617–3624 (1992).

  15. 15.

    MacIntyre, I. et al. Proc. Natl Acad. Sci. USA 88, 2936–2940 (1991).

Download references

Author information

Competing interests

The authors declare no competing interests.

Correspondence to Mone Zaidi.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark
Fig. 1: The supportive and destructive functions of type H endothelial cells.