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MECHANOBIOLOGY

Golgi mechanics controls lipid metabolism

Cell metabolism ensures that cell dynamics and continued renewal are supported by a constant flow of matter that consumes energy. A new study shows that cell metabolism is sensitive to mechanical cues, revealing that the level of cell contraction modulates the production and storage of lipids, which could serve as fuel for energy production.

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References

  1. 1.

    Ivanovska, I. L., Shin, J.-W., Swift, J. & Discher, D. E. Trends Cell Biol. 25, 523–532 (2015).

  2. 2.

    Streichan, S. J., Hoerner, C. R., Schneidt, T., Holzer, D. & Hufnagel, L. Proc. Natl Acad. Sci. USA 111, 5586–5591 (2014).

  3. 3.

    McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. & Chen, C. S. Dev. Cell 6, 483–495 (2004).

  4. 4.

    Palm, W. & Thompson, C. B. Nature 546, 234–242 (2017).

  5. 5.

    Ata, R. & Antonescu, C. N. Int. J. Mol. Sci. 18, (2017).

  6. 6.

    Bays, J. L., Campbell, H. K., Heidema, C., Sebbagh, M. & DeMali, K. A. Nat. Cell Biol. 19, 724–731 (2017).

  7. 7.

    Romani, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0270-5 (2019).

  8. 8.

    Kim, J. Y. et al. Cell 175, 133–145 (2018).

  9. 9.

    Walker, A. K. et al. Cell 147, 840–852 (2011).

  10. 10.

    Schiller, H. B. et al. Nat. Cell Biol. 15, 625–636 (2013).

  11. 11.

    Mendez, M. G. & Janmey, P. A. Int. J. Biochem. Cell Biol. 44, 728–732 (2012).

  12. 12.

    Peterson, T. R. et al. Cell 146, 408–420 (2011).

  13. 13.

    Han, H. et al. R Mol. Cell 72, 328–340e8 (2018).

  14. 14.

    Meng, Z. et al. Nature 560, 655–660 (2018).

  15. 15.

    Guet, D. et al. Curr. Biol. 24, 1700–1711 (2014).

  16. 16.

    Rashid, T. et al. EMBO J. 38, e99576 (2018).

Download references

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The authors declare no competing interests.

Correspondence to Manuel Théry or Mario Pende.

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Fig. 1: Mechanotransduction at the Golgi.