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MECHANOBIOLOGY

Golgi mechanics controls lipid metabolism

Nature Cell Biology volume 21, pages 301–302 (2019)Cite this article

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Cell metabolism ensures that cell dynamics and continued renewal are supported by a constant flow of matter that consumes energy. A new study shows that cell metabolism is sensitive to mechanical cues, revealing that the level of cell contraction modulates the production and storage of lipids, which could serve as fuel for energy production.

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Fig. 1: Mechanotransduction at the Golgi.

References

  1. Ivanovska, I. L., Shin, J.-W., Swift, J. & Discher, D. E. Trends Cell Biol. 25, 523–532 (2015).

    Article  Google Scholar 

  2. Streichan, S. J., Hoerner, C. R., Schneidt, T., Holzer, D. & Hufnagel, L. Proc. Natl Acad. Sci. USA 111, 5586–5591 (2014).

    Article  CAS  Google Scholar 

  3. McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. & Chen, C. S. Dev. Cell 6, 483–495 (2004).

    Article  CAS  Google Scholar 

  4. Palm, W. & Thompson, C. B. Nature 546, 234–242 (2017).

    Article  CAS  Google Scholar 

  5. Ata, R. & Antonescu, C. N. Int. J. Mol. Sci. 18, (2017).

  6. Bays, J. L., Campbell, H. K., Heidema, C., Sebbagh, M. & DeMali, K. A. Nat. Cell Biol. 19, 724–731 (2017).

    Article  CAS  Google Scholar 

  7. Romani, P. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0270-5 (2019).

  8. Kim, J. Y. et al. Cell 175, 133–145 (2018).

    Article  CAS  Google Scholar 

  9. Walker, A. K. et al. Cell 147, 840–852 (2011).

    Article  CAS  Google Scholar 

  10. Schiller, H. B. et al. Nat. Cell Biol. 15, 625–636 (2013).

    Article  CAS  Google Scholar 

  11. Mendez, M. G. & Janmey, P. A. Int. J. Biochem. Cell Biol. 44, 728–732 (2012).

    Article  CAS  Google Scholar 

  12. Peterson, T. R. et al. Cell 146, 408–420 (2011).

    Article  CAS  Google Scholar 

  13. Han, H. et al. R Mol. Cell 72, 328–340e8 (2018).

    Article  CAS  Google Scholar 

  14. Meng, Z. et al. Nature 560, 655–660 (2018).

    Article  CAS  Google Scholar 

  15. Guet, D. et al. Curr. Biol. 24, 1700–1711 (2014).

    Article  CAS  Google Scholar 

  16. Rashid, T. et al. EMBO J. 38, e99576 (2018).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Université Grenoble-Alpes, CEA, CNRS, INRA, Biosciences & Biotechnology Institute of Grenoble, Laboratoire de Phyiologie Cellulaire & Végétale, CytoMorpho Lab, Grenoble, France

    Manuel Théry

  2. Université Paris Diderot, INSERM, CEA, Hôpital Saint Louis, Institut Universitaire d’Hematologie, UMRS1160, CytoMorpho Lab, Paris, France

    Manuel Théry

  3. Institut Necker-Enfants Malades, Paris, France

    Mario Pende

  4. Inserm, U1151, Paris, France

    Mario Pende

  5. Université Paris Descartes, Sorbonne Paris Cité, Paris, France

    Mario Pende

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  1. Manuel Théry
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  2. Mario Pende
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Correspondence to Manuel Théry or Mario Pende.

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The authors declare no competing interests.

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Théry, M., Pende, M. Golgi mechanics controls lipid metabolism. Nat Cell Biol 21, 301–302 (2019). https://doi.org/10.1038/s41556-019-0289-2

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